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The best solution for WordPress optimization we discovered is W3 Total Cache plugin http://WordPress.org/extend/plugins/w3-total-cache/ , however for best results it should be configured properly.

Here are settings that achieved best results during our tests:

1. Page Cache = Disk (Enhanced)

2. Minify Cache = Opcode

3. Database Cache = Opcode

4. Object Cache = Opcode

For Opcode you can install any of PHP caching engines like APC, XCache or eAccelerator .

However you should understand that website speed depends on many other things, like mysql database speed, number of static files per page, different plugins, etc.

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